Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.62 |
| ▸ | HSD17B1 | P14061 | 6/20 | 0.49 |
| ▸ | HSD17B2 | P37059 | 6/20 | 0.49 |
| ▸ | PGR | P06401 | 4/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | HSD17B14 | Q9BPX1 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20056522 | 0.82 | HSD17B1 (0.63) | ESR2HSD17B1HSD17B2TLR8FGFR1 | |
| SCHEMBL12668310 | 0.77 | HSD17B1 (0.60) | ESR2HSD17B1HSD17B2HSD17B14FGFR1 | |
| SCHEMBL1513516 | 0.77 | HSD17B1 (0.60) | ESR2HSD17B1HSD17B2HSD17B14FGFR1 | |
| SCHEMBL20056622 | 0.77 | ESR2 (0.58) | ESR2HSD17B1HSD17B2MEN1KMT2A | |
| SCHEMBL31574448 | 0.77 | HSD17B1 (0.63) | ESR2HSD17B1HSD17B2FGFR1TP53 | |
| SCHEMBL675046 | 0.77 | HSD17B1 (0.63) | ESR2HSD17B1HSD17B2FGFR1TP53 | |
| SCHEMBL29696046 | 0.77 | HSD17B1 (0.68) | ESR2HSD17B1HSD17B2FGFR1TP53 | |
| SCHEMBL29429121 | 0.77 | HSD17B1 (0.68) | ESR2HSD17B1HSD17B2FGFR1TP53 | |
| SCHEMBL272034 | 0.77 | HSD17B1 (0.68) | ESR2HSD17B1HSD17B2FGFR1TP53 | |
| SCHEMBL26979937 | 0.77 | HSD17B1 (0.68) | ESR2HSD17B1HSD17B2FGFR1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970353-B1 | MANNOSE DERIVATIVES FOR TREATING BACTERIAL INFECTIONS | VERTEX PHARMA (US) | 2018-04-18 | — | — | EP | disclosed |