Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 5/20 | 0.32 |
| ▸ | PRKDC | P78527 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL610864 | 0.69 | SMN1; SMN2 (0.39) | PIK3CGPRKDC | |
| SCHEMBL612940 | 0.62 | SMN1; SMN2 (0.50) | — | |
| SCHEMBL24908210 | 0.62 | LRRK2 (0.33) | — | |
| SCHEMBL23564729 | 0.59 | HTT (0.46) | PIK3CGPRKDC | |
| SCHEMBL3319742 | 0.59 | HDAC2 (0.36) | — | |
| SCHEMBL2148413 | 0.58 | L3MBTL1 (0.57) | — | |
| SCHEMBL18948352 | 0.56 | PIK3CG (0.54) | PIK3CGPRKDC | |
| SCHEMBL11918297 | 0.56 | PIK3CG (0.40) | PIK3CGPRKDC | |
| SCHEMBL15462088 | 0.56 | PIK3CG (0.51) | PIK3CGPRKDC | |
| SCHEMBL13275224 | 0.56 | LRRK2 (0.33) | PIK3CGPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3808739-A1 | ISOINDOLINONE INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE | Vertex Pharmaceuticals Incorporated (US) | 2021-04-21 | — | — | EP | disclosed |
| EP-3309152-B1 | ISOINDOLINONE INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE | VERTEX PHARMA (US) | 2020-09-09 | — | — | EP | disclosed |
| EP-3309152-A1 | ISOINDOLINONE INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE | Vertex Pharmaceuticals Incorporated (US) | 2018-04-18 | — | — | EP | disclosed |