Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | CMA1 | P23946 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | CTSD | P07339 | 2/20 | 0.31 |
| ▸ | BACE1 | P56817 | 2/20 | 0.31 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | MAT2A | P31153 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23564961 | 0.72 | HTT (0.42) | HTTROCK1GPR119 | |
| SCHEMBL7684177 | 0.71 | HTT (0.46) | HTTCMA1TDP1GPR119 | |
| SCHEMBL8721237 | 0.68 | HTT (0.39) | HTT | |
| SCHEMBL9232299 | 0.67 | HTT (0.54) | HTTCMA1TDP1GPR119 | |
| SCHEMBL31743952 | 0.66 | AURKA (0.44) | LRRK2JAK2MAT2A | |
| SCHEMBL13275224 | 0.65 | LRRK2 (0.33) | ROCK1LRRK2PIK3CGPRKDCMAT2A | |
| SCHEMBL8718617 | 0.64 | HTT (0.54) | HTTCMA1TDP1GPR119 | |
| SCHEMBL2148413 | 0.64 | L3MBTL1 (0.57) | ROCK1 | |
| SCHEMBL3518937 | 0.63 | HTT (0.62) | HTTTDP1GPR119 | |
| SCHEMBL612940 | 0.63 | SMN1; SMN2 (0.50) | HTTCTSDBACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127459-A1 | GPR139 RECEPTOR MODULATORS | BLACKTHORN THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |