Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.44 |
| ▸ | F10 | P00742 | 3/20 | 0.36 |
| ▸ | PTGIR | P43119 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20060917 | 0.92 | GPR119 (0.46) | GPR119KCNH2HTR1ADRD2HTR2A | |
| SCHEMBL22311301 | 0.85 | NR1H2 (0.49) | GPR119KCNH2PTGIRHTR1ADRD2 | |
| SCHEMBL22311299 | 0.85 | NR1H2 (0.49) | GPR119KCNH2PTGIRHTR1ADRD2 | |
| SCHEMBL25549350 | 0.85 | NR1H2 (0.49) | GPR119KCNH2PTGIRHTR1ADRD2 | |
| SCHEMBL25547752 | 0.83 | GPR119 (0.44) | GPR119KCNH2PTGIRHTR1ADRD2 | |
| SCHEMBL20060926 | 0.82 | NR1H2 (0.39) | GPR119KCNH2 | |
| SCHEMBL22311049 | 0.80 | GPR119 (0.43) | GPR119KCNH2HTR1ADRD2HTR2A | |
| SCHEMBL22311060 | 0.80 | GPR119 (0.46) | GPR119KCNH2HTR1ADRD2HTR2A | |
| SCHEMBL22311061 | 0.80 | GPR119 (0.46) | GPR119KCNH2HTR1ADRD2HTR2A | |
| SCHEMBL22310515 | 0.79 | GPR119 (0.42) | GPR119KCNH2HTR1ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018068295-A1 | ARYL AND HETEROARYL ETHER DERIVATIVES AS LIVER X RECEPTOR β AGONISTS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |
| WO-2018071317-A1 | ARYL AND HETEROARYL ETHER DERIVATIVES AS LIVER X RECEPTOR BETA AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |