Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | PTGIR | P43119 | 2/20 | 0.38 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22311299 | 0.91 | NR1H2 (0.49) | GPR119KCNH2NR1H2NR1H3PTGIR | |
| SCHEMBL22311301 | 0.91 | NR1H2 (0.49) | GPR119KCNH2NR1H2NR1H3PTGIR | |
| SCHEMBL25549350 | 0.91 | NR1H2 (0.49) | GPR119KCNH2NR1H2NR1H3PTGIR | |
| SCHEMBL22310515 | 0.85 | GPR119 (0.42) | GPR119KCNH2NR1H2NR1H3HTR1A | |
| SCHEMBL22311060 | 0.84 | GPR119 (0.46) | GPR119KCNH2NR1H2NR1H3HTR1A | |
| SCHEMBL22311061 | 0.84 | GPR119 (0.46) | GPR119KCNH2NR1H2NR1H3HTR1A | |
| SCHEMBL20060908 | 0.83 | GPR119 (0.44) | GPR119KCNH2PTGIRHTR1ADRD2 | |
| SCHEMBL20061066 | 0.82 | NR1H2 (0.46) | GPR119KCNH2NR1H2NR1H3PTGIR | |
| SCHEMBL22311051 | 0.82 | NR1H2 (0.46) | GPR119KCNH2NR1H2NR1H3PTGIR | |
| SCHEMBL25547247 | 0.80 | NR1H2 (0.64) | GPR119KCNH2NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11655216-B2 | Aryl and heteroaryl ether derivatives as liver X receptor beta agonists, compositions, and their use | MERCK SHARP & DOHME LLC (US) | 2023-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11655216-B2 | Aryl and heteroaryl ether derivatives as liver X receptor beta agonists, compositions, and their use | NR1H2, NR1H3, NR1H4 | GPR119 15/4885KCNH2 2600/4885NR1H2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.