Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20060942 | 0.83 | THRB (0.43) | THRBRECQLTDP1POLBL3MBTL1 | |
| SCHEMBL20060900 | 0.76 | THRB (0.46) | THRBRECQLTDP1POLBL3MBTL1 | |
| SCHEMBL20061075 | 0.75 | THRB (0.47) | THRBRECQLTDP1POLBL3MBTL1 | |
| SCHEMBL29966096 | 0.75 | KDM4E (0.54) | KMT2ANPC1MAPTRAB9ACASP1 | |
| SCHEMBL2468448 | 0.75 | KDM4E (0.54) | KMT2ANPC1MAPTRAB9ACASP1 | |
| SCHEMBL13617723 | 0.74 | THRB (0.65) | THRBKMT2AMAPTTHRAMEN1 | |
| SCHEMBL2104774 | 0.72 | PARP10 (0.56) | POLBKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20068690 | 0.71 | ALDH1A1 (0.41) | THRBRECQLTDP1POLBL3MBTL1 | |
| SCHEMBL20068521 | 0.71 | HDAC3 (0.50) | TDP1POLBKMT2ANPC1MAPT | |
| SCHEMBL9198133 | 0.71 | SIRT2 (0.51) | THRBPOLBKMT2ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018068295-A1 | ARYL AND HETEROARYL ETHER DERIVATIVES AS LIVER X RECEPTOR β AGONISTS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |