Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 6/20 | 0.50 |
| ▸ | MTOR | P42345 | 4/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22200768 | 0.69 | PIK3CA (0.42) | PIK3CAMTORFGFR1FGFR2FGFR4 | |
| SCHEMBL29501260 | 0.68 | NNMT (0.42) | PIK3CADHFRHTTCSF1R | |
| SCHEMBL5753276 | 0.68 | CDK4 (0.45) | FGFR1 | |
| SCHEMBL22200749 | 0.68 | PIK3CA (0.56) | PIK3CAMTORFGFR1FGFR2FGFR4 | |
| SCHEMBL2006204 | 0.67 | PIK3CA (1.00) | PIK3CAMTOR | |
| SCHEMBL22200607 | 0.65 | PIK3CA (0.48) | PIK3CAMTORFGFR1FGFR2FGFR4 | |
| SCHEMBL4283863 | 0.65 | PIK3CA (0.48) | PIK3CAMTORFGFR1FGFR2FGFR4 | |
| SCHEMBL5266289 | 0.65 | CDK4 (0.57) | FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL25034118 | 0.64 | ERN1 (0.50) | PIK3CAMTORFGFR1FGFR2FGFR4 | |
| SCHEMBL3175950 | 0.63 | CYP3A4 (0.50) | PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074122-B9 | PYRIDO (2, 3-D) PYRIMIDIN0NE COMPOUNDS AND THEIR USE AS PI3 INHIBITORS | PFIZER PROD INC (US) | 2013-09-11 | — | — | EP | disclosed |
| EP-2074122-B1 | PYRIDO (2, 3-D) PYRIMIDIN0NE COMPOUNDS AND THEIR USE AS PI3 INHIBITORS | PFIZER PROD INC (US) | 2011-06-29 | — | — | EP | disclosed |