SCHEMBL20062960

SCHEMBL20062960

CC(C)(C)c1ccc2c(c1)N(c1ccc(-c3ccccc3)s1)/C(=C1\N(c3ccc(-c4ccccc4)s3)c3ccc(C(C)(C)C)cc3N1c1ccc(-c3ccccc3)s1)N2c1ccc(-c2ccccc2)s1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AR P10275 1/20 0.38
HSD17B1 P14061 3/20 0.36
HSD17B2 P37059 3/20 0.36
PRKDC P78527 2/20 0.36
CYP2E1 P05181 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2A6 P11509 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2B6 P20813 1/20 0.33
CYP2C19 P33261 1/20 0.33
NQO2 P16083 1/20 0.33
RXRA P19793 1/20 0.32
RXRB P28702 1/20 0.32
KIF11 P52732 1/20 0.32
NR1H3 Q13133 1/20 0.31
OPRL1 P41146 1/20 0.30
KDM4E B2RXH2 1/20 0.30
NPC1 O15118 1/20 0.30
ALDH1A1 P00352 1/20 0.30
HPGD P15428 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20071774 0.84 AR (0.38) ARHSD17B1HSD17B2PRKDCCYP2E1
SCHEMBL20062963 0.79 MAPT (0.31) ALDH1A1HPGDMAPK1
SCHEMBL20062966 0.75 RXRB (0.33) PRKDCRXRARXRB
SCHEMBL18905680 0.75 TSHR (0.38) KIF11NR1H3NPC1ALDH1A1HPGD
SCHEMBL18905689 0.75 TSHR (0.38) KIF11NR1H3NPC1ALDH1A1HPGD
SCHEMBL20097508 0.72 HSD17B1 (0.55) HSD17B1HSD17B2CYP2E1CYP3A4CYP2A6
SCHEMBL20062879 0.72 MEN1 (0.39) RXRARXRBKIF11NR1H3NPC1
SCHEMBL17994290 0.70 HSD17B1 (0.52) HSD17B1HSD17B2CYP2E1CYP3A4CYP2A6
SCHEMBL20062958 0.70 PRKDC (0.34) PRKDCCYP2E1CYP3A4CYP2A6CYP2C9
SCHEMBL18905694 0.70 NOTUM (0.39) ARRXRARXRBKIF11NR1H3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180108691-A1 ORGANIC PHOTOELECTRIC CONVERSION ELEMENT, OPTICAL AREA SENSOR, IMAGING DEVICE, AND IMAGING APPARATUS CANON KABUSHIKI KAISHA (JP) 2018-04-19 US disclosed