Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 18/20 | 0.78 |
| ▸ | RAB9A | P51151 | 1/20 | 0.67 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.67 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20063101 | 0.91 | PHGDH (0.79) | PHGDHRAB9ACACNA1BAPBA1KMT2A | |
| SCHEMBL20063103 | 0.89 | PHGDH (0.76) | PHGDHRAB9ACACNA1BAPBA1KMT2A | |
| SCHEMBL20063106 | 0.88 | PHGDH (0.74) | PHGDHRAB9ACACNA1BAPBA1KMT2A | |
| SCHEMBL20063099 | 0.88 | PHGDH (0.74) | PHGDHRAB9ACACNA1BAPBA1KMT2A | |
| SCHEMBL20063098 | 0.88 | PHGDH (0.83) | PHGDHRAB9ACACNA1BAPBA1KMT2A | |
| SCHEMBL20063094 | 0.87 | PHGDH (1.00) | PHGDHRAB9ACACNA1BAPBA1KMT2A | |
| SCHEMBL28408134 | 0.87 | PHGDH (0.74) | PHGDH | |
| SCHEMBL20063102 | 0.86 | PHGDH (0.72) | PHGDHRAB9ACACNA1BAPBA1KMT2A | |
| SCHEMBL20063139 | 0.85 | PHGDH (0.85) | PHGDHRAB9ACACNA1BAPBA1KMT2A | |
| SCHEMBL20063104 | 0.85 | PHGDH (0.71) | PHGDHRAB9ACACNA1BAPBA1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11225469-B2 | Inhibitors of phosphoglycerate dehydrogenase (PHGDH) and uses thereof | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2022-01-18 | — | — | US | disclosed |
| US-20180105508-A1 | INHIBITORS OF PHOSPHOGLYCERATE DEHYDROGENASE (PHGDH) AND USES THEREOF | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2018-04-19 | — | — | US | disclosed |
| US-20180105508-A1 | INHIBITORS OF PHOSPHOGLYCERATE DEHYDROGENASE (PHGDH) AND USES THEREOF | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2018-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11225469-B2 | Inhibitors of phosphoglycerate dehydrogenase (PHGDH) and uses thereof | PHGDH, PGD, PGK1 | PHGDH 1/4885RAB9A 1994/4885CACNA1B 4648/4885 |
| US-20180105508-A1 | INHIBITORS OF PHOSPHOGLYCERATE DEHYDROGENASE (PHGDH) AND USES THEREOF | PHGDH, PGD, PGK1 | PHGDH 1/4885RAB9A 2026/4885CACNA1B 4598/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.