Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.47 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.42 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 10/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 10/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30939096 | 0.77 | MALT1 (0.43) | USP30PANK3MALT1HRH3JAK2 | |
| SCHEMBL20064025 | 0.77 | HRH3 (0.42) | USP30PANK3MALT1HRH3JAK2 | |
| SCHEMBL19689542 | 0.77 | HRH3 (0.45) | USP30PANK3MALT1HRH3JAK2 | |
| SCHEMBL31472937 | 0.77 | HRH3 (0.45) | USP30PANK3MALT1HRH3JAK2 | |
| SCHEMBL20064053 | 0.74 | USP30 (0.46) | USP30CHRM4 | |
| SCHEMBL27055566 | 0.73 | CHRNB2 (0.43) | USP30HRH3JAK2JAK1TYK2 | |
| SCHEMBL22637164 | 0.73 | MAP3K12 (0.49) | USP30PANK3HRH3JAK2JAK1 | |
| SCHEMBL19689490 | 0.72 | PANK3 (0.44) | USP30PANK3MALT1HRH3HCRTR1 | |
| SCHEMBL20064451 | 0.71 | PANK3 (0.49) | USP30PANK3MALT1HRH3HCRTR1 | |
| SCHEMBL31472951 | 0.71 | CNR2 (0.51) | USP30PANK3MALT1HRH3HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018069863-A1 | 1,3 DI-SUBSTITUTED CYCLOBUTANE OR AZETIDINE DERIVATIVES AS HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-04-19 | — | — | WO | disclosed |