Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.44 |
| ▸ | GRM1 | Q13255 | 5/20 | 0.44 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.44 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13449831 | 0.88 | CA12 (0.50) | USP30GRM1PLD1KAT2BALDH1A1 | |
| SCHEMBL20065110 | 0.88 | CA12 (0.50) | USP30GRM1PLD1KAT2BALDH1A1 | |
| SCHEMBL29969592 | 0.78 | KDM4E (0.49) | USP30GRIN2BGRM1PLD1KAT2B | |
| SCHEMBL20064228 | 0.77 | KDM4E (0.43) | GRM1KDM4ECHRM4 | |
| SCHEMBL2005995 | 0.76 | USP30 (0.54) | USP30GRIN2BGRM1CYP3A4CYP2D6 | |
| SCHEMBL20064573 | 0.75 | GRIN2D (0.41) | GRIN2BGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7711658 | 0.74 | HRH3 (0.48) | CYP3A4ALDH1A1KDM4E | |
| SCHEMBL20063997 | 0.74 | USP30 (0.47) | USP30CHRM4 | |
| SCHEMBL28768958 | 0.73 | HSD11B1 (0.49) | GRIN2BGRM1PLD1CYP3A4CYP2D6 | |
| SCHEMBL23875353 | 0.72 | PLD1 (0.52) | GRIN2BGRM1PLD1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018069863-A1 | 1,3 DI-SUBSTITUTED CYCLOBUTANE OR AZETIDINE DERIVATIVES AS HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-04-19 | — | — | WO | disclosed |