Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PARK7 | Q99497 | 3/20 | 0.38 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.38 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10446579 | 0.86 | ALDH1A1 (0.41) | PLA2G2AALDH1A1LMNASMN1; SMN2TDP1 | |
| SCHEMBL9101479 | 0.80 | HSD17B3 (0.48) | KDM4EGPR84 | |
| SCHEMBL537992 | 0.78 | MEN1 (0.48) | HTR2AALDH1A1LMNASMN1; SMN2TDP1 | |
| SCHEMBL19584807 | 0.77 | ALDH1A1 (0.40) | ALDH1A1LMNAPOLBKDM4E | |
| SCHEMBL16191048 | 0.77 | HTR2A (0.51) | HTR2AHTR2CALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL27318275 | 0.75 | MAPT (0.41) | ALDH1A1SMN1; SMN2KDM4EHTT | |
| SCHEMBL17006077 | 0.75 | ALDH1A1 (0.35) | HTR2AHTR2CALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4139935 | 0.74 | ALDH1A1 (0.43) | ALDH1A1LMNASMN1; SMN2POLBRAB9A | |
| SCHEMBL31021773 | 0.74 | ALDH1A1 (0.40) | ALDH1A1LMNASMN1; SMN2POLBKDM4E | |
| SCHEMBL8429903 | 0.74 | ALOX15 (0.46) | HTR2AHTR2CPOLBRAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018069863-A1 | 1,3 DI-SUBSTITUTED CYCLOBUTANE OR AZETIDINE DERIVATIVES AS HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-04-19 | — | — | WO | disclosed |