Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 1/20 | 0.37 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.37 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.37 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11877444 | 0.78 | — | — | |
| SCHEMBL28121150 | 0.74 | GAA (0.33) | GNAI3GNAO1GNAI1SPHK1GAA | |
| SCHEMBL24764887 | 0.74 | KDM1A (0.32) | — | |
| SCHEMBL28346839 | 0.74 | TSHR (0.37) | GAA | |
| SCHEMBL11587514 | 0.74 | GAA (0.34) | GNAI3GNAO1GNAI1GAA | |
| SCHEMBL22561602 | 0.72 | — | — | |
| SCHEMBL23696685 | 0.71 | LMNA (0.31) | — | |
| SCHEMBL25568270 | 0.70 | — | — | |
| SCHEMBL25568273 | 0.70 | — | — | |
| SCHEMBL730844 | 0.69 | GNAI3 (0.34) | GNAI3GNAO1GNAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018069863-A1 | 1,3 DI-SUBSTITUTED CYCLOBUTANE OR AZETIDINE DERIVATIVES AS HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-04-19 | — | — | WO | disclosed |