Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | GRM5 | P41594 | 2/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13534139 | 0.84 | GRIN2D (0.53) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL9913868 | 0.82 | FFAR4 (0.44) | FFAR4GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL22150460 | 0.78 | SLC6A2 (0.35) | GRIN1GRIN2BCYP4F2CYP4A11SLC6A2 | |
| SCHEMBL20325313 | 0.78 | SLC6A2 (0.33) | GRIN1GRIN2BALDH1A1CYP4F2CYP4A11 | |
| SCHEMBL28014799 | 0.78 | EPHX2 (0.42) | FFAR4GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL24196240 | 0.75 | GRIN2D (0.49) | FFAR4GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL20064585 | 0.75 | ALDH1A1 (0.48) | ALDH1A1SLC6A2SLC6A4SLC6A3OPRK1 | |
| SCHEMBL22560560 | 0.74 | EPHX2 (0.33) | SLC6A2SLC6A4SLC6A3EPHX2OPRM1 | |
| SCHEMBL19510585 | 0.74 | FFAR4 (0.40) | FFAR4GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL3037790 | 0.73 | EPHX2 (0.48) | FFAR4GRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018069863-A1 | 1,3 DI-SUBSTITUTED CYCLOBUTANE OR AZETIDINE DERIVATIVES AS HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-04-19 | — | — | WO | disclosed |