Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 17/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20064230 | 0.91 | PDE4A (0.45) | PDE4APDE4DPDE4BPDE4CKCNH2 | |
| SCHEMBL24345432 | 0.82 | HTR2C (0.45) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL23717311 | 0.82 | PDE4A (0.46) | PDE4APDE4DPDE4BPDE4CKCNH2 | |
| SCHEMBL13799356 | 0.81 | PDE4A (0.61) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL21533928 | 0.81 | DUT (0.41) | PDE4APDE4B | |
| SCHEMBL20064317 | 0.81 | PDE4D (0.53) | PDE4APDE4DPDE4BPDE4CKCNH2 | |
| SCHEMBL20063995 | 0.80 | PDE4D (0.51) | PDE4APDE4DPDE4BPDE4CKCNH2 | |
| SCHEMBL13450374 | 0.80 | PDE4A (0.40) | PDE4APDE4B | |
| SCHEMBL18501195 | 0.79 | HRH3 (0.42) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL24313936 | 0.78 | HTR2C (0.40) | PDE4APDE4DPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018069863-A1 | 1,3 DI-SUBSTITUTED CYCLOBUTANE OR AZETIDINE DERIVATIVES AS HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-04-19 | — | — | WO | disclosed |