Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 12/20 | 0.53 |
| ▸ | PDE4A | P27815 | 11/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.53 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6876750 | 0.97 | PDE4D (0.56) | PDE4DPDE4APDE4BPDE4CSYK | |
| SCHEMBL20064213 | 0.83 | SLC6A4 (0.46) | PDE4DPDE4APDE4BPDE4CSYK | |
| SCHEMBL20063995 | 0.82 | PDE4D (0.51) | PDE4DPDE4APDE4BPDE4CKCNH2 | |
| SCHEMBL20064209 | 0.81 | PDE4A (0.54) | PDE4DPDE4APDE4BPDE4CKCNH2 | |
| SCHEMBL131273 | 0.81 | PDE4A (0.50) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL14345864 | 0.80 | ALDH1A1 (0.51) | PDE4DPDE4APDE4BPDE4CALDH1A1 | |
| SCHEMBL16120951 | 0.80 | HTR2C (0.45) | SYK | |
| SCHEMBL20064269 | 0.80 | PDE4A (0.53) | PDE4DPDE4APDE4BPDE4CKCNH2 | |
| SCHEMBL5759440 | 0.78 | PDE4D (0.51) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL6873641 | 0.78 | PDE4A (0.60) | PDE4DPDE4APDE4BPDE4CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018069863-A1 | 1,3 DI-SUBSTITUTED CYCLOBUTANE OR AZETIDINE DERIVATIVES AS HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-04-19 | — | — | WO | disclosed |