Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 13/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.47 |
| ▸ | PDE4A | P27815 | 5/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31619159 | 0.97 | PDE4D (0.51) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL5759440 | 0.87 | PDE4D (0.51) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL31619151 | 0.85 | PDE4D (0.53) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL498509 | 0.85 | PDE4D (0.53) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL3122679 | 0.82 | TRPA1 (0.43) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL5758960 | 0.82 | DRD1 (0.48) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL28806357 | 0.79 | PDE4D (0.47) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL17003829 | 0.79 | PDE4D (0.57) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL17003826 | 0.79 | PDE4D (0.57) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL31590778 | 0.79 | PDE4B (0.57) | PDE4DPDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018069863-A1 | 1,3 DI-SUBSTITUTED CYCLOBUTANE OR AZETIDINE DERIVATIVES AS HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-04-19 | — | — | WO | disclosed |