Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 2/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.46 |
| ▸ | PDE4A | P27815 | 5/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5759440 | 0.95 | PDE4D (0.51) | DRD1PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL498509 | 0.94 | PDE4D (0.53) | DRD1PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL31619151 | 0.94 | PDE4D (0.53) | DRD1PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL28806357 | 0.88 | PDE4D (0.47) | DRD1PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7143854 | 0.85 | PDE4D (0.60) | DRD1PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL29440132 | 0.85 | DRD1 (0.53) | DRD1PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL140841 | 0.85 | DRD1 (0.53) | DRD1PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL20064241 | 0.82 | PDE4D (0.48) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL22713946 | 0.81 | ALDH1A1 (0.68) | PDE4BPDE4DPDE4APDE4CALDH1A1 | |
| SCHEMBL8845986 | 0.80 | PDE4B (0.49) | PDE4BPDE4DPDE4APDE4CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113121894-B | Wear-resistant anti-slip rubber | 浙江中瑞橡胶高分子材料股份有限公司 | 2022-04-05 | — | — | CN | claimed |
| CN-113121894-A | Wear-resistant anti-slip rubber | 浙江中瑞橡胶高分子材料股份有限公司 | 2021-07-16 | — | — | CN | claimed |
| CN-115197190-A | Novel plant flavone derivative and preparation method and application thereof | 中国海洋大学 | 2022-10-18 | — | — | CN | disclosed |
| CN-113121894-B | Wear-resistant anti-slip rubber | 浙江中瑞橡胶高分子材料股份有限公司 | 2022-04-05 | — | — | CN | disclosed |
| CN-113121894-A | Wear-resistant anti-slip rubber | 浙江中瑞橡胶高分子材料股份有限公司 | 2021-07-16 | — | — | CN | disclosed |
| EP-1272488-B1 | TRI-ARYL-SUBSTITUTED-ETHANE PDE4 INHIBITORS | MERCK FROSST CANADA INC (CA) | 2006-03-22 | — | — | EP | disclosed |
| US-20060004056-A1 | Di-aryl-substituted-ethan pyridone pde4 inhibitors | MERCK FROSST CANADA LTD. (CA) | 2006-01-05 | — | — | US | disclosed |
| EP-1519922-A1 | DI-ARYL-SUBSTITUTED ETHANE PYRIDONE PDE4 INHIBITORS | Merck Frosst Canada & Co. (CA) | 2005-04-06 | — | — | EP | disclosed |
| US-6841564-B2 | Tri-aryl-substituted-ethane PDE4 inhibitors | MERCK FROSST CANADA & CO. (CA) | 2005-01-11 | — | — | US | disclosed |
| WO-2004005258-A1 | DI-ARYL-SUBSTITUTED-ETHANE PYRIDONE PDE4 INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2004-01-15 | — | — | WO | disclosed |
| US-6639077-B2 | Ethanes substituted with a phenyl, a thiazole, and a pyridyl are phosphodiesterase (PDE4) inhibitors; leukotriene receptor antagonists | MERCK FROSST CANADA & CO. (CA) | 2003-10-28 | — | — | US | disclosed |
| EP-1272488-A2 | TRI-ARYL-SUBSTITUTED-ETHANE PDE4 INHIBITORS | MERCK FROSST CANADA INC. (CA) | 2003-01-08 | — | — | EP | disclosed |
| US-20020173661-A1 | Tri-aryl-substituted-ethane PDE4 inhibitors | MERCK FROSST CANADA & CO. | 2002-11-21 | — | — | US | disclosed |
| US-20020156105-A1 | Tri-aryl-substituted-ethane PDE4 inhibitors | MERCK FROSST CANADA LTD. (CA) | 2002-10-24 | — | — | US | disclosed |
| US-6399636-B2 | FOR THERAPY OF ASTHMA, CHRONIC BRONCHITIS, CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD), EOSINOPHILIC GRANULOMA, PSORIASIS AND SEPTIC SHOCK, ULCERATIVE COLITIS, CROHN'S DISEASE, REPERFUSION INJURY OF THE MYOCARDIUM AND BRAIN | MERCK FROSST CANADA & CO. (CA) | 2002-06-04 | — | — | US | disclosed |
| US-20020013347-A1 | Tri-aryl-substituted-ethane PDE4 inhibitors | MERCK FROSST CANADA LTD. (CA) | 2002-01-31 | — | — | US | disclosed |
| EP-1157007-A1 | PDE IV INHIBITING COMPOUNDS, COMPOSITIONS AND METHODS OF TREATMENT | MERCK FROSST CANADA INC. (CA) | 2001-11-28 | — | — | EP | disclosed |
| WO-2001070738-A2 | TRI-ARYL-SUBSTITUTED-ETHANE PDE4 INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2001-09-27 | — | — | WO | disclosed |
| US-6204275-B1 | PDE IV inhibiting compounds, compositions and methods of treatment | MERCK FROSST CANADA & CO. (CA) | 2001-03-20 | — | — | US | disclosed |
| WO-2000050402-A1 | PDE IV INHIBITING COMPOUNDS, COMPOSITIONS AND METHODS OF TREATMENT | MERCK FROSST CANADA & CO. (CA) | 2000-08-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020173661-A1 | Tri-aryl-substituted-ethane PDE4 inhibitors | PDE4A, PDE4B, PDE3A | DRD1 2507/4885PDE4B 2/4885PDE4D 7/4885 |
| US-20020156105-A1 | Tri-aryl-substituted-ethane PDE4 inhibitors | PDE4A, PDE4B, PDE3A | DRD1 2507/4885PDE4B 2/4885PDE4D 7/4885 |
| US-20020013347-A1 | Tri-aryl-substituted-ethane PDE4 inhibitors | PDE4A, PDE4B, PDE3A | DRD1 2597/4885PDE4B 2/4885PDE4D 5/4885 |
| US-20060004056-A1 | Di-aryl-substituted-ethan pyridone pde4 inhibitors | PDE4A, PTGER4, IL4 | DRD1 1947/4885PDE4B 4/4885PDE4D 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.