Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 5/20 | 0.48 |
| ▸ | GRM5 | P41594 | 3/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NMT1 | P30419 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20064279 | 0.83 | KDM4E (0.49) | MCHR1JAK2JAK1TYK2JAK3 | |
| SCHEMBL21222061 | 0.79 | ENPP2 (0.38) | HPGDS | |
| SCHEMBL20064263 | 0.79 | ENPP2 (0.38) | HPGDS | |
| SCHEMBL9050436 | 0.77 | MCHR1 (0.57) | MCHR1KDM4EMEN1NPC1RAB9A | |
| SCHEMBL20064274 | 0.76 | HPGDS (0.43) | GRM5JAK2JAK1TYK2JAK3 | |
| Hydrochloric Acid SCHEMBL9051831 | 0.76 | MCHR1 (0.56) | MCHR1KDM4EMEN1NPC1RAB9A | |
| SCHEMBL23858507 | 0.75 | HPGDS (0.60) | MCHR1HTR1AHPGDSKDM4EMEN1 | |
| SCHEMBL30081475 | 0.75 | HPGDS (0.60) | MCHR1HTR1AHPGDSKDM4EMEN1 | |
| SCHEMBL4887893 | 0.74 | MCHR1 (0.61) | MCHR1KDM4EMEN1NPC1RAB9A | |
| SCHEMBL3717235 | 0.74 | JAK2 (0.50) | MCHR1JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018069863-A1 | 1,3 DI-SUBSTITUTED CYCLOBUTANE OR AZETIDINE DERIVATIVES AS HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-04-19 | — | — | WO | disclosed |