Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.50 |
| ▸ | COPS5 | Q92905 | 2/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | CCR1 | P32246 | 3/20 | 0.42 |
| ▸ | CCR8 | P51685 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10157939 | 0.82 | HTT (0.58) | HTTPSMD14COPS5SLC6A2CCR1 | |
| SCHEMBL28423616 | 0.78 | L3MBTL1 (0.53) | HTTPSMD14COPS5SLC6A2CCR1 | |
| SCHEMBL29459602 | 0.78 | L3MBTL1 (0.53) | HTTPSMD14COPS5SLC6A2CCR1 | |
| SCHEMBL11515706 | 0.77 | KDM4E (0.64) | HTTSLC6A2L3MBTL1NPC1KDM4E | |
| SCHEMBL31026573 | 0.77 | L3MBTL1 (0.52) | CCR1CCR8L3MBTL1NPC1HSP90AA1 | |
| SCHEMBL1416783 | 0.77 | L3MBTL1 (0.52) | CCR1CCR8L3MBTL1NPC1HSP90AA1 | |
| SCHEMBL28067774 | 0.77 | HTT (0.56) | HTTPSMD14COPS5SLC6A2CCR1 | |
| SCHEMBL31026570 | 0.77 | L3MBTL1 (0.52) | CCR1CCR8L3MBTL1NPC1HSP90AA1 | |
| SCHEMBL31026586 | 0.77 | L3MBTL1 (0.52) | CCR1CCR8L3MBTL1NPC1HSP90AA1 | |
| SCHEMBL27455037 | 0.76 | CYP1A2 (0.50) | HTTKDM4ETDP1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018069863-A1 | 1,3 DI-SUBSTITUTED CYCLOBUTANE OR AZETIDINE DERIVATIVES AS HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-04-19 | — | — | WO | disclosed |