Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20064689 | 0.96 | MCHR1 (0.40) | MCHR1ALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL20064563 | 0.76 | MCHR1 (0.52) | MCHR1ALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL20064360 | 0.74 | MCHR1 (0.41) | MCHR1 | |
| SCHEMBL927638 | 0.74 | ALDH1A1 (0.55) | ALDH1A1KDM4EMEN1MAPTPKM | |
| SCHEMBL5884276 | 0.71 | MCHR1 (0.82) | MCHR1 | |
| SCHEMBL20327732 | 0.70 | NR1I2 (0.33) | ALDH1A1KDM4E | |
| SCHEMBL20064627 | 0.70 | MCHR1 (0.40) | MCHR1 | |
| SCHEMBL926186 | 0.70 | ALDH1A1 (0.50) | MCHR1ALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL5588579 | 0.70 | ALDH1A1 (0.43) | MCHR1ALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL20783232 | 0.68 | ALDH1A1 (0.33) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018069863-A1 | 1,3 DI-SUBSTITUTED CYCLOBUTANE OR AZETIDINE DERIVATIVES AS HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-04-19 | — | — | WO | disclosed |