Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20065619 | 0.96 | MCHR1 (0.41) | MCHR1ALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL20327732 | 0.75 | NR1I2 (0.33) | ALDH1A1KDM4E | |
| SCHEMBL20064627 | 0.74 | MCHR1 (0.40) | MCHR1 | |
| SCHEMBL20064563 | 0.72 | MCHR1 (0.52) | MCHR1ALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL20064628 | 0.71 | DRD2 (0.42) | MCHR1 | |
| SCHEMBL5589442 | 0.71 | ALOX5 (0.42) | MCHR1ALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL20064360 | 0.70 | MCHR1 (0.41) | MCHR1 | |
| SCHEMBL5587093 | 0.70 | ALOX5 (0.41) | MCHR1ALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL5587997 | 0.70 | ALOX5 (0.41) | MCHR1ALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL5588873 | 0.70 | ALOX5 (0.41) | MCHR1ALDH1A1KDM4EMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018069863-A1 | 1,3 DI-SUBSTITUTED CYCLOBUTANE OR AZETIDINE DERIVATIVES AS HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-04-19 | — | — | WO | disclosed |