SCHEMBL2006599

SCHEMBL2006599

COc1ccc2c(c1)c(C(=O)c1nc(-c3cccnc3)cs1)c(C)n2Cc1ccc(Cl)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PLA2G2A P14555 3/20 0.49
ALDH1A1 P00352 3/20 0.49
MAPT P10636 2/20 0.49
CYP1A2 P05177 2/20 0.49
CYP3A4 P08684 2/20 0.49
TSHR P16473 2/20 0.49
MEN1 O00255 1/20 0.49
RGS12 O14924 1/20 0.49
LMNA P02545 1/20 0.49
CYP2C9 P11712 1/20 0.49
PKM P14618 1/20 0.49
NFKB1 P19838 1/20 0.49
MAPK1 P28482 1/20 0.49
CYP2C19 P33261 1/20 0.49
GNAI1 P63096 1/20 0.49
PMP22 Q01453 1/20 0.49
KMT2A Q03164 1/20 0.49
HIF1A Q16665 1/20 0.49
PTGS2 P35354 8/20 0.45
CYP19A1 P11511 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2004319 0.92 ALDH1A1 (0.52) PLA2G2AALDH1A1MAPTCYP1A2CYP3A4
SCHEMBL2002503 0.88 IRAK4 (0.51) PLA2G2AALDH1A1MAPTCYP1A2CYP3A4
SCHEMBL2002829 0.87 PLA2G2A (0.49) PLA2G2AALDH1A1MAPTCYP1A2CYP3A4
SCHEMBL2001326 0.86 PLA2G2A (0.50) PLA2G2AALDH1A1MAPTCYP1A2CYP3A4
SCHEMBL2002207 0.85 PLA2G2A (0.49) PLA2G2AALDH1A1MAPTCYP1A2CYP3A4
SCHEMBL2007180 0.85 PLA2G2A (0.50) PLA2G2AALDH1A1MAPTCYP1A2CYP3A4
SCHEMBL2009911 0.85 PLA2G2A (0.50) PLA2G2AALDH1A1MAPTCYP1A2CYP3A4
SCHEMBL2000164 0.84 AHR (0.50) ALDH1A1MAPTCYP1A2CYP3A4LMNA
SCHEMBL2004620 0.83 PLA2G2A (0.49) PLA2G2AALDH1A1MAPTCYP1A2CYP3A4
SCHEMBL2008959 0.83 PLA2G2A (0.49) PLA2G2AALDH1A1MAPTCYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7960544-B2 Useful indole compounds IRONWOOD PHARMACEUTICALS, INC. (US) 2011-06-14 US disclosed