Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | ROS1 | P08922 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20067130 | 0.87 | CSNK1G1 (0.41) | SMN1; SMN2ALDH1A1RAB9AKDM4ENPC1 | |
| SCHEMBL20067134 | 0.87 | ROS1 (0.42) | SMN1; SMN2ALDH1A1RAB9AKDM4ENPC1 | |
| SCHEMBL8204921 | 0.81 | MAPT (0.41) | SMN1; SMN2ALDH1A1KDM4EGAAMAPT | |
| SCHEMBL7456203 | 0.80 | TRPA1 (0.43) | GAAMAPTTP53TRPA1MEN1 | |
| SCHEMBL309794 | 0.80 | MAPT (0.50) | SMN1; SMN2ALDH1A1KDM4EGAAMAPT | |
| SCHEMBL20067137 | 0.76 | TRPA1 (0.47) | GAAMAPTTRPA1 | |
| SCHEMBL8203046 | 0.75 | GAA (0.41) | GAAMAPTTRPA1MEN1KMT2A | |
| SCHEMBL20067132 | 0.74 | MAPT (0.50) | ALDH1A1RAB9ANPC1HTTMAPT | |
| SCHEMBL4673880 | 0.74 | TRPA1 (0.58) | SMN1; SMN2ALDH1A1KDM4EHTTMAPT | |
| SCHEMBL30285272 | 0.73 | MAPT (0.64) | SMN1; SMN2ALDH1A1RAB9AKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3310765-B1 | PROCESS FOR PREPARING 1,4-DIBENZODIAZEPINES VIA BUCHWALD-HARTWIG CHEMISTRY | UNIV EVORA (PT) | 2019-06-12 | — | — | EP | disclosed |
| US-10208001-B2 | Process for preparing 1,4-dibenzodiazepines via Buchwald-Hartwig chemistry | UNIVERSIDADE DE EVORA (PT) | 2019-02-19 | — | — | US | disclosed |
| US-20180105502-A1 | PROCESS FOR PREPARING 1,4-DIBENZODIAZEPINES VIA BUCHWALD-HARTWIG CHEMISTRY | UNIVERSIDADE DE EVORA (PT) | 2018-04-19 | — | — | US | disclosed |
| US-20180105502-A1 | PROCESS FOR PREPARING 1,4-DIBENZODIAZEPINES VIA BUCHWALD-HARTWIG CHEMISTRY | UNIVERSIDADE DE EVORA (PT) | 2018-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10208001-B2 | Process for preparing 1,4-dibenzodiazepines via Buchwald-Hartwig chemistry | HRH2, HRH4, HRH1 | SMN1; SMN2 3533/4885ALDH1A1 235/4885RAB9A 1993/4885 |
| US-20180105502-A1 | PROCESS FOR PREPARING 1,4-DIBENZODIAZEPINES VIA BUCHWALD-HARTWIG CHEMISTRY | HRH2, HRH4, HRH1 | SMN1; SMN2 3533/4885ALDH1A1 235/4885RAB9A 1993/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.