Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 7/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20068107 | 0.91 | SIRT2 (1.00) | SIRT2LMNAALDH1A1MAPTUSP2 | |
| SCHEMBL20067930 | 0.85 | SIRT2 (0.74) | SIRT2LMNAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL20067983 | 0.83 | SIRT2 (0.74) | SIRT2LMNAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL20067935 | 0.83 | SIRT2 (0.71) | SIRT2LMNAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL20067965 | 0.83 | SIRT2 (0.79) | SIRT2LMNAALDH1A1MAPTUSP2 | |
| SCHEMBL20067974 | 0.82 | LMNA (0.77) | SIRT2LMNAALDH1A1POLBMAPT | |
| SCHEMBL20067976 | 0.81 | SIRT2 (0.69) | SIRT2LMNAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL20067986 | 0.81 | SIRT2 (0.69) | SIRT2LMNAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL20067941 | 0.81 | ALDH1A1 (0.74) | SIRT2LMNAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL20067961 | 0.81 | SIRT2 (0.72) | SIRT2LMNAALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018068357-A1 | NOVEL SIRT2 PROTEIN INHIBITOR AND PHARMACEUTICAL USE THEREOF | 西华大学 | 2018-04-19 | — | — | WO | disclosed |