Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.69 |
| ▸ | LMNA | P02545 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 2/20 | 0.53 |
| ▸ | GALR3 | O60755 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20068103 | 0.91 | SIRT2 (0.72) | SIRT2LMNAALDH1A1HTTMAPT | |
| SCHEMBL20067954 | 0.87 | SIRT2 (0.66) | SIRT2LMNAALDH1A1HTTMAPT | |
| SCHEMBL20067948 | 0.84 | SIRT2 (0.66) | SIRT2LMNAALDH1A1HTTMAPT | |
| SCHEMBL20067930 | 0.83 | SIRT2 (0.74) | SIRT2LMNAALDH1A1HTTMAPT | |
| SCHEMBL20067949 | 0.82 | SIRT2 (0.69) | SIRT2LMNAALDH1A1HTTMAPT | |
| SCHEMBL20067931 | 0.81 | SIRT2 (1.00) | SIRT2LMNAALDH1A1HTTMAPT | |
| SCHEMBL20067935 | 0.81 | SIRT2 (0.71) | SIRT2LMNAALDH1A1HTTMAPT | |
| SCHEMBL20067983 | 0.81 | SIRT2 (0.74) | SIRT2LMNAALDH1A1MAPTCYP1A2 | |
| SCHEMBL20067965 | 0.81 | SIRT2 (0.79) | SIRT2LMNAALDH1A1HTTMAPT | |
| SCHEMBL20067974 | 0.81 | LMNA (0.77) | SIRT2LMNAALDH1A1HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018068357-A1 | NOVEL SIRT2 PROTEIN INHIBITOR AND PHARMACEUTICAL USE THEREOF | 西华大学 | 2018-04-19 | — | — | WO | disclosed |