Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.72 |
| ▸ | LMNA | P02545 | 5/20 | 0.65 |
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | USP2 | O75604 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | RGS12 | O14924 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20067965 | 0.93 | SIRT2 (0.79) | SIRT2LMNAGAAMAPTUSP2 | |
| SCHEMBL20067930 | 0.85 | SIRT2 (0.74) | SIRT2LMNAGAAMAPTUSP2 | |
| SCHEMBL20068107 | 0.84 | SIRT2 (1.00) | SIRT2LMNAGAAMAPTUSP2 | |
| SCHEMBL20068003 | 0.82 | SIRT2 (0.71) | SIRT2LMNAGAAMAPTUSP2 | |
| SCHEMBL18306579 | 0.81 | MAPT (0.82) | SIRT2LMNAGAAMAPTUSP2 | |
| SCHEMBL20067944 | 0.81 | SIRT2 (0.72) | SIRT2LMNAGAAMAPTUSP2 | |
| SCHEMBL20067982 | 0.81 | SIRT2 (0.76) | SIRT2LMNAGAAMAPTUSP2 | |
| SCHEMBL20067928 | 0.81 | SIRT2 (0.76) | SIRT2LMNAGAAMAPTUSP2 | |
| SCHEMBL22640037 | 0.80 | MAPT (0.85) | SIRT2LMNAGAAMAPTMEN1 | |
| SCHEMBL13856720 | 0.80 | ALDH1A1 (0.65) | SIRT2LMNAGAAMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018068357-A1 | NOVEL SIRT2 PROTEIN INHIBITOR AND PHARMACEUTICAL USE THEREOF | 西华大学 | 2018-04-19 | — | — | WO | disclosed |