Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 3/20 | 0.40 |
| ▸ | PGR | P06401 | 2/20 | 0.40 |
| ▸ | AR | P10275 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.35 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16613939 | 1.00 | NR3C1 (0.40) | NR3C1PGRARPTGS1NR3C2 | |
| SCHEMBL16614004 | 0.92 | NR3C1 (0.42) | NR3C1PGRARPTGS1NR3C2 | |
| SCHEMBL20068222 | 0.92 | NR3C1 (0.42) | NR3C1PGRARPTGS1NR3C2 | |
| SCHEMBL30402420 | 0.91 | NR3C1 (0.40) | NR3C1PGRARPTGS1NR3C2 | |
| SCHEMBL20068185 | 0.89 | NR3C1 (0.40) | NR3C1PGRARPTGS1NR3C2 | |
| SCHEMBL20068224 | 0.89 | NR3C1 (0.39) | NR3C1PGRARPTGS1NR3C2 | |
| SCHEMBL20068225 | 0.89 | NR3C1 (0.39) | NR3C1PGRARPTGS1NR3C2 | |
| SCHEMBL20068223 | 0.89 | NR3C1 (0.41) | NR3C1PGRARPTGS1NR3C2 | |
| SCHEMBL20068221 | 0.89 | NR3C1 (0.52) | NR3C1PGRARPTGS1NR3C2 | |
| SCHEMBL20169789 | 0.85 | KDM4E (0.38) | KDM4EMEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10954265-B2 | Structures and mechanism for the design of highly potent glucocorticoids | VAN ANDEL RESEARCH INSTITUTE (US) | 2021-03-23 | — | — | US | disclosed |
| US-20190263853-A1 | STRUCTURES AND MECHANISM FOR THE DESIGN OF HIGHLY POTENT GLUCOCORTICOIDS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-08-29 | — | — | US | disclosed |
| WO-2018071736-A1 | STRUCTURES AND MECHANISM FOR THE DESIGN OF HIGHLY POTENT GLUCOCORTICOIDS | VAN ANDEL RESEARCH INSTITUTE (US) | 2018-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190263853-A1 | STRUCTURES AND MECHANISM FOR THE DESIGN OF HIGHLY POTENT GLUCOCORTICOIDS | NR3C1, NR3C2, MC2R | NR3C1 1/4885PGR 99/4885AR 42/4885 |
| US-10954265-B2 | Structures and mechanism for the design of highly potent glucocorticoids | NR3C1, NR3C2, MC2R | NR3C1 1/4885PGR 99/4885AR 42/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.