Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.31 |
| ▸ | GABRD | O14764 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.31 |
| ▸ | GABRE | P78334 | 1/20 | 0.31 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.31 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20068370 | 0.84 | SMN1; SMN2 (0.39) | BTKKMT2ASMN1; SMN2TSHRPOLB | |
| SCHEMBL23798668 | 0.69 | BTK (0.38) | BTKHSD17B10KMT2ASMN1; SMN2LMNA | |
| SCHEMBL20068383 | 0.69 | BTK (0.38) | BTKHSD17B10KMT2ASMN1; SMN2LMNA | |
| SCHEMBL22310390 | 0.69 | BTK (0.38) | BTKHSD17B10KMT2ASMN1; SMN2LMNA | |
| SCHEMBL5264559 | 0.69 | HRH3 (0.46) | BTKHSD17B10KMT2ASMN1; SMN2LMNA | |
| SCHEMBL1072603 | 0.69 | HRH3 (0.46) | BTKHSD17B10KMT2ASMN1; SMN2LMNA | |
| SCHEMBL10328238 | 0.69 | HRH3 (0.46) | BTKHSD17B10KMT2ASMN1; SMN2LMNA | |
| Tert-Butyl Hydroperoxide SCHEMBL28692274 | 0.65 | ALDH1A1 (0.45) | BTKHSD17B10KMT2ASMN1; SMN2LMNA | |
| SCHEMBL23420382 | 0.65 | LMNA (0.43) | BTKHSD17B10KMT2ASMN1; SMN2LMNA | |
| SCHEMBL15238175 | 0.65 | BTK (0.43) | BTKHSD17B10KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071314-A1 | TRICYCLIC SULFONES AS ROR GAMMA MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-04-19 | — | — | WO | disclosed |