Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 5/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 4/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20061055 | 0.86 | GPR119 (0.47) | NR1H2NR1H3PDK2GPR119HRH3 | |
| SCHEMBL20060927 | 0.86 | GPR119 (0.47) | NR1H2NR1H3PDK2GPR119HRH3 | |
| SCHEMBL20060961 | 0.85 | NR1H2 (0.61) | NR1H2NR1H3PDK2HRH3RXRA | |
| SCHEMBL30452735 | 0.85 | NR1H2 (0.61) | NR1H2NR1H3PDK2HRH3RXRA | |
| SCHEMBL20060963 | 0.85 | NR1H2 (0.61) | NR1H2NR1H3PDK2HRH3RXRA | |
| SCHEMBL22284449 | 0.85 | NR1H2 (0.61) | NR1H2NR1H3PDK2HRH3RXRA | |
| SCHEMBL20068723 | 0.84 | NR1H2 (0.42) | NR1H2NR1H3PDK2GPR119HRH3 | |
| SCHEMBL20061078 | 0.83 | GPR119 (0.39) | NR1H2NR1H3PDK2GPR119FFAR1 | |
| SCHEMBL20068697 | 0.81 | NR1H2 (0.42) | NR1H2NR1H3PDK2 | |
| SCHEMBL20060962 | 0.81 | GPR119 (0.51) | NR1H2NR1H3GPR119RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071317-A1 | ARYL AND HETEROARYL ETHER DERIVATIVES AS LIVER X RECEPTOR BETA AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |