Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20060927 | 1.00 | GPR119 (0.47) | GPR119NR1H2NR1H3HRH3PDK2 | |
| SCHEMBL20060866 | 0.91 | GPR119 (0.44) | GPR119NR1H2NR1H3HRH3PDK2 | |
| SCHEMBL20060864 | 0.91 | GPR119 (0.43) | GPR119NR1H2NR1H3HRH3PDK2 | |
| SCHEMBL20060885 | 0.90 | PDK2 (0.41) | GPR119NR1H2NR1H3PDK2THRA | |
| SCHEMBL20060889 | 0.89 | PDK2 (0.41) | GPR119NR1H2NR1H3HRH3PDK2 | |
| SCHEMBL20068692 | 0.88 | GPR119 (0.49) | GPR119NR1H2NR1H3HRH3 | |
| SCHEMBL20068723 | 0.88 | NR1H2 (0.42) | GPR119NR1H2NR1H3HRH3PDK2 | |
| SCHEMBL22310514 | 0.88 | GPR119 (0.41) | GPR119MAOB | |
| SCHEMBL20060849 | 0.87 | UTS2R (0.41) | GPR119THRATHRB | |
| SCHEMBL20060844 | 0.86 | GPR119 (0.46) | GPR119HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018068295-A1 | ARYL AND HETEROARYL ETHER DERIVATIVES AS LIVER X RECEPTOR β AGONISTS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |