Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.40 |
| ▸ | THRB | P10828 | 4/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20068551 | 0.89 | GPR119 (0.53) | GPR119 | |
| SCHEMBL20061079 | 0.86 | THRB (0.39) | HRH3GPR119THRBTHRA | |
| SCHEMBL30451268 | 0.81 | NR1H2 (0.48) | HRH3GPR119 | |
| SCHEMBL20061081 | 0.81 | NR1H2 (0.48) | HRH3GPR119 | |
| SCHEMBL20061083 | 0.81 | NR1H2 (0.48) | HRH3GPR119 | |
| SCHEMBL20061027 | 0.80 | GPR119 (0.63) | GPR119 | |
| SCHEMBL30450940 | 0.80 | GPR119 (0.63) | GPR119 | |
| SCHEMBL20068585 | 0.80 | GPR119 (0.63) | GPR119 | |
| SCHEMBL22284369 | 0.80 | GPR119 (0.63) | GPR119 | |
| SCHEMBL20068695 | 0.80 | HCRTR1 (0.36) | HRH3GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071317-A1 | ARYL AND HETEROARYL ETHER DERIVATIVES AS LIVER X RECEPTOR BETA AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |