Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.68 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.66 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.66 |
| ▸ | NPC1 | O15118 | 5/20 | 0.64 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | GRM5 | P41594 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3989785 | 0.85 | JAK2 (0.60) | RAB9ANPC1KCNK3SMN1; SMN2MEN1 | |
| SCHEMBL6918701 | 0.84 | GRM5 (0.67) | ALDH1A1GRM5 | |
| SCHEMBL23015754 | 0.82 | RAB9A (0.64) | RAB9ATDP1ROCK2ROCK1NPC1 | |
| SCHEMBL23015729 | 0.82 | TDP1 (0.66) | RAB9ATDP1ROCK2ROCK1NPC1 | |
| SCHEMBL259177 | 0.81 | TDP1 (0.78) | RAB9ATDP1ROCK2ROCK1NPC1 | |
| SCHEMBL19662756 | 0.81 | NT5E (0.71) | RAB9ANPC1KCNK3MEN1KMT2A | |
| SCHEMBL28777431 | 0.81 | TDP1 (1.00) | RAB9ATDP1ROCK2ROCK1NPC1 | |
| SCHEMBL14880208 | 0.80 | ROCK2 (1.00) | RAB9ATDP1ROCK2ROCK1NPC1 | |
| SCHEMBL1971026 | 0.79 | NAMPT (0.78) | RAB9ATDP1ROCK2ROCK1NPC1 | |
| SCHEMBL30828594 | 0.79 | HDAC4 (0.64) | RAB9ANPC1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10927106-B2 | Benzothiazole derivatives as DYRK1 inhibitors | PHARMASUM THERAPEUTICS AS (NO) | 2021-02-23 | — | — | US | disclosed |
| WO-2018069468-A1 | BENZOTHIAZOLE DERIVATIVES AS DYRK1 INHIBITORS | PHARMASUM THERAPEUTICS AS (NO) | 2018-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10927106-B2 | Benzothiazole derivatives as DYRK1 inhibitors | DYRK1A, DYRK1B, PDK2 | RAB9A 1200/4885TDP1 780/4885ROCK2 902/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.