Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ME3 | Q16798 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20148028 | 0.84 | POLB (0.51) | POLBKMT2ALMNAMAPTL3MBTL1 | |
| SCHEMBL25505311 | 0.81 | POLB (0.51) | POLBKMT2ALMNAMAPTL3MBTL1 | |
| SCHEMBL20068839 | 0.80 | ALDH1A1 (0.49) | POLBKMT2ALMNAMAPTL3MBTL1 | |
| SCHEMBL25505300 | 0.80 | POLB (0.48) | POLBKMT2ALMNAMAPTL3MBTL1 | |
| SCHEMBL24515851 | 0.69 | LMNA (0.57) | POLBKMT2ALMNAMAPTL3MBTL1 | |
| SCHEMBL25641853 | 0.69 | LMNA (0.57) | POLBKMT2ALMNAMAPTL3MBTL1 | |
| SCHEMBL24515840 | 0.69 | LMNA (0.57) | POLBKMT2ALMNAMAPTL3MBTL1 | |
| SCHEMBL29215851 | 0.68 | POLB (0.58) | POLBKMT2AMAPTNPC1RAB9A | |
| SCHEMBL30268809 | 0.68 | POLB (0.58) | POLBKMT2AMAPTNPC1RAB9A | |
| SCHEMBL11861632 | 0.68 | POLB (0.61) | POLBKMT2ALMNAMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |