Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | SSTR4 | P31391 | 3/20 | 0.38 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | MYC | P01106 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20148704 | 0.85 | PDE10A (0.44) | PDE10ARETPDE2ACSF1RSSTR4 | |
| SCHEMBL20069584 | 0.81 | P2RX7 (0.43) | RETPDE2AHRH4HCRTR2HCRTR1 | |
| SCHEMBL20069577 | 0.77 | L3MBTL1 (0.51) | PDE10ARETGRM5 | |
| SCHEMBL20069586 | 0.73 | HDAC1 (0.43) | RETPDE2AGRM5 | |
| SCHEMBL20069578 | 0.73 | PIK3CD (0.51) | — | |
| SCHEMBL20069573 | 0.72 | PDE10A (0.46) | PDE10ARETPDE2ACSF1RHCRTR2 | |
| SCHEMBL20069582 | 0.72 | SIRT3 (0.46) | RET | |
| SCHEMBL14818783 | 0.70 | NPC1 (0.56) | PDE10ACSF1R | |
| SCHEMBL20069571 | 0.70 | PDE10A (0.44) | PDE10ARETPDE2ACSF1RGRM5 | |
| SCHEMBL20069581 | 0.70 | TDP1 (0.44) | PDE10ARETCSF1RHCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3753939-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | Array Biopharma Inc. (US) | 2020-12-23 | — | — | EP | disclosed |
| EP-3523301-B1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2020-05-27 | — | — | EP | disclosed |
| WO-2018071447-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |