Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | SCN1A | P35498 | 1/20 | 0.30 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.30 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20069715 | 0.89 | DRD2 (0.45) | KDM5ADRD2CHRM1CCNA2CDK2 | |
| SCHEMBL17672878 | 0.80 | KDM5A (0.52) | KDM5ADRD2CHRM1CCR1RET | |
| SCHEMBL22856999 | 0.79 | DRD2 (0.46) | KDM5ADRD2CHRM1TSHRRET | |
| SCHEMBL20147472 | 0.79 | KDM5A (0.48) | KDM5ADRD2CHRM1CCR1 | |
| SCHEMBL24720248 | 0.78 | DRD2 (0.35) | DRD2USP2SCN1ASCN2ASCN3A | |
| SCHEMBL20147973 | 0.77 | DRD2 (0.44) | KDM5ADRD2CHRM1RETALDH1A1 | |
| SCHEMBL20147474 | 0.75 | KDM5A (0.44) | KDM5ADRD2CHRM1CCR1ALDH1A1 | |
| SCHEMBL17682649 | 0.74 | KDM5A (0.47) | KDM5ACHRM1USP2HPGD | |
| SCHEMBL17033041 | 0.72 | PKM (0.44) | KDM5ADRD2CHRM1CCNA2CDK2 | |
| SCHEMBL21651941 | 0.71 | RET (0.37) | KDM5ADRD2CHRM1RETSCN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |