Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 2/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.33 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18347993 | 0.87 | CHRNB4 (0.36) | CHRNB4CHRNA3CTSKSSTR1SSTR4 | |
| SCHEMBL20147505 | 0.83 | CHRNB4 (0.37) | RETCHRNB4CHRNA3CTSK | |
| SCHEMBL21651943 | 0.81 | CHRNB4 (0.38) | RETCHRNB4CHRNA3CTSKKDM4E | |
| SCHEMBL20147928 | 0.81 | CHRNB4 (0.35) | RETCHRNB4CHRNA3CTSK | |
| SCHEMBL20158582 | 0.79 | CHRNB4 (0.34) | RETCHRNB4CHRNA3CTSK | |
| SCHEMBL15980408 | 0.78 | OGA (0.38) | SSTR1SSTR4 | |
| SCHEMBL20070143 | 0.77 | HSD11B1 (0.40) | RETCHRNB4CHRNA3CTSKSSTR1 | |
| SCHEMBL20069720 | 0.77 | SMN1; SMN2 (0.39) | RETCTSKSSTR1SSTR4 | |
| SCHEMBL20148065 | 0.75 | RET (0.38) | RETSSTR1SSTR4 | |
| SCHEMBL18361599 | 0.74 | SSTR1 (0.37) | SSTR1SSTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |