Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 9/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | CCR3 | P51677 | 1/20 | 0.44 |
| ▸ | WDR5 | P61964 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20205997 | 0.89 | RET (0.49) | RETKMT2AP2RX7CCR3WDR5 | |
| SCHEMBL20068927 | 0.87 | CCR3 (0.45) | RETP2RX7CCR3MAPK1CYP2D6 | |
| SCHEMBL20147543 | 0.86 | RET (0.50) | RETP2RX7CCR3 | |
| SCHEMBL20068931 | 0.86 | RET (0.47) | RETCCR3 | |
| SCHEMBL20069762 | 0.83 | CCR3 (0.44) | RETP2RX7CCR3MAPK1CYP2D6 | |
| SCHEMBL20069672 | 0.82 | RET (0.46) | RETCCR3WDR5MAPK1 | |
| SCHEMBL20069763 | 0.82 | PIN1 (0.48) | RETKMT2ACCR3LMNATP53 | |
| SCHEMBL20069757 | 0.82 | RET (0.43) | RETP2RX7CCR3WDR5MAPK1 | |
| SCHEMBL20069742 | 0.81 | KMT2A (0.54) | KMT2AP2RX7WDR5CYP2D6 | |
| SCHEMBL20069741 | 0.79 | RET (0.46) | RETCCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |