Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 15/20 | 0.45 |
| ▸ | CXCR5 | P32302 | 4/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20069741 | 0.90 | RET (0.46) | RET | |
| SCHEMBL20068931 | 0.86 | RET (0.47) | RET | |
| SCHEMBL20147546 | 0.85 | RET (0.40) | RETCXCR5HDAC4 | |
| SCHEMBL20147554 | 0.80 | RET (0.45) | RET | |
| SCHEMBL20152062 | 0.79 | RET (0.42) | RET | |
| SCHEMBL21651991 | 0.78 | CCR3 (0.49) | RET | |
| SCHEMBL20147539 | 0.78 | RET (0.46) | RET | |
| SCHEMBL20069762 | 0.76 | CCR3 (0.44) | RETHDAC4 | |
| SCHEMBL20069671 | 0.75 | RET (0.52) | RETHDAC4 | |
| SCHEMBL20068927 | 0.74 | CCR3 (0.45) | RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |