Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 2/20 | 0.63 |
| ▸ | CTSB | P07858 | 2/20 | 0.63 |
| ▸ | CTSK | P43235 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.55 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 2/20 | 0.53 |
| ▸ | DRD4 | P21917 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.51 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20962706 | 0.90 | MEN1 (0.62) | CTSLCTSBCTSKMEN1KMT2A | |
| SCHEMBL994466 | 0.81 | CTSL (0.63) | CTSLCTSBCTSKMEN1KMT2A | |
| SCHEMBL358264 | 0.81 | CTSL (0.63) | CTSLCTSBCTSKMEN1KMT2A | |
| SCHEMBL10274561 | 0.81 | CTSL (0.63) | CTSLCTSBCTSKMEN1KMT2A | |
| SCHEMBL25692665 | 0.80 | CTSL (0.62) | CTSLCTSBCTSKMEN1KMT2A | |
| SCHEMBL24371203 | 0.79 | CTSL (0.60) | CTSLCTSBCTSKMEN1KMT2A | |
| SCHEMBL22652448 | 0.79 | CTSL (0.60) | CTSLCTSBCTSKMEN1KMT2A | |
| SCHEMBL27553686 | 0.79 | CTSL (0.60) | CTSLCTSBCTSKMEN1KMT2A | |
| SCHEMBL20201377 | 0.79 | CTSL (0.60) | CTSLCTSBCTSKMEN1KMT2A | |
| SCHEMBL10168794 | 0.78 | HRH3 (0.67) | CTSLCTSBCTSKMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |