Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 10/20 | 0.45 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | GPR6 | P46095 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | HTR1F | P30939 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20147559 | 0.87 | RET (0.43) | RETCCR3DRD2GPR6USP30 | |
| SCHEMBL20147990 | 0.87 | RET (0.43) | RETCCR3DRD2GPR6USP30 | |
| SCHEMBL20069757 | 0.82 | RET (0.43) | RETCCR3USP30 | |
| SCHEMBL20069763 | 0.81 | PIN1 (0.48) | RETCCR3 | |
| SCHEMBL20068927 | 0.80 | CCR3 (0.45) | RETCCR3DRD2USP30HTR1F | |
| SCHEMBL20070357 | 0.79 | RET (0.47) | RETCCR3GPR6USP30 | |
| SCHEMBL20069668 | 0.76 | MAPK1 (0.44) | RETCCR3HTR1FMCHR1 | |
| SCHEMBL20068931 | 0.76 | RET (0.47) | RETCCR3DRD2 | |
| SCHEMBL20069734 | 0.75 | RET (0.50) | RETCCR3 | |
| SCHEMBL22857021 | 0.74 | USP30 (0.39) | RETCCR3USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |