Sugi Predict

Sugi Predict / Compounds / SCHEMBL20069802

SCHEMBL20069802

SCHEMBL20069802

COc1ccc(CN2C3CC2CN(C(C)C)C3)c(C)c1

nearest known ligand 0.42

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ KDM1A O60341 1/20 0.42
▸ MAOA P21397 1/20 0.42
▸ MAOB P27338 1/20 0.42
▸ RET P07949 1/20 0.41
▸ PDE2A O00408 1/20 0.37
▸ TSHR P16473 1/20 0.35
▸ KDM2B Q8NHM5 1/20 0.34
▸ S1PR1 P21453 1/20 0.34
▸ S1PR5 Q9H228 1/20 0.34
▸ DRD2 P14416 3/20 0.34
▸ DRD3 P35462 3/20 0.34
▸ ALDH1A1 P00352 3/20 0.34
▸ GAA P10253 1/20 0.34
▸ LMNA P02545 1/20 0.33
▸ HPGD P15428 1/20 0.33
▸ APOBEC3A P31941 1/20 0.33
▸ APOBEC3G Q9HC16 1/20 0.33
▸ TACR1 P25103 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20153218 0.85 KDM1A (0.44) KDM1AMAOAMAOBRETPDE2A
SCHEMBL22811855 0.84 RET (0.43) KDM1AMAOAMAOBRETPDE2A
SCHEMBL20069809 0.80 ALDH1A1 (0.48) ALDH1A1LMNA
SCHEMBL20149595 0.78 RET (0.43) RET
SCHEMBL20149599 0.76 RET (0.44) RETKDM2B
SCHEMBL20070794 0.76 PDE10A (0.34) RET
SCHEMBL20149630 0.74 RET (0.45) RETALDH1A1LMNA
SCHEMBL20070543 0.73 RET (0.41) RET
SCHEMBL20149597 0.72 RET (0.43) KDM1AMAOAMAOBRET
SCHEMBL20070793 0.70 RET (0.45) RET

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240066029-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2024-02-29 — — US disclosed
US-20180133200-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-17 — — US disclosed
US-20180133213-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-17 — — US disclosed
US-20180134702-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-17 — — US disclosed
WO-2018071447-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ANDREWS STEVEN W (US) 2018-04-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180134702-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, ROR1, BRAF KDM1A 998/4885MAOA 3390/4885MAOB 2737/4885
US-20180133200-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, ROR1, BRAF KDM1A 998/4885MAOA 3390/4885MAOB 2737/4885
US-20180133213-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, ROR1, BRAF KDM1A 998/4885MAOA 3390/4885MAOB 2737/4885
US-20240066029-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, ROR1, BRAF KDM1A 998/4885MAOA 3390/4885MAOB 2737/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.