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SCHEMBL20153218

SCHEMBL20153218

COc1ccc(CN2C3CC2CN(C)C3)c(C)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM1A O60341 1/20 0.44
▸ MAOA P21397 1/20 0.44
▸ MAOB P27338 1/20 0.44
▸ RET P07949 1/20 0.42
▸ PDE2A O00408 1/20 0.39
▸ L3MBTL1 Q9Y468 1/20 0.37
▸ S1PR1 P21453 1/20 0.36
▸ S1PR5 Q9H228 1/20 0.36
▸ ALDH1A1 P00352 3/20 0.35
▸ DRD2 P14416 3/20 0.35
▸ GAA P10253 2/20 0.35
▸ DRD3 P35462 2/20 0.35
▸ KMT2A Q03164 1/20 0.35
▸ HPGD P15428 1/20 0.35
▸ APOBEC3A P31941 1/20 0.35
▸ APOBEC3G Q9HC16 1/20 0.35
▸ HTR3E A5X5Y0 1/20 0.35
▸ HTR3B O95264 1/20 0.35
▸ HTR3A P46098 1/20 0.35
▸ HTR3D Q70Z44 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22811855 0.88 RET (0.43) KDM1AMAOAMAOBRETPDE2A
SCHEMBL20069802 0.85 KDM1A (0.42) KDM1AMAOAMAOBRETPDE2A
SCHEMBL20070782 0.76 RET (0.45) RET
SCHEMBL22031278 0.74 RET (0.34) RET
SCHEMBL20070524 0.74 RET (0.48) RETALDH1A1GAAKMT2A
SCHEMBL20154572 0.72 RET (0.47) RETALDH1A1GAAKMT2AHRH3
SCHEMBL20069798 0.72 SIGMAR1 (0.55) KDM1AMAOAMAOBALDH1A1KMT2A
SCHEMBL21158877 0.71 RET (0.42) RET
SCHEMBL18212504 0.70 S1PR1 (0.44) KDM1AMAOAMAOBPDE2AL3MBTL1
SCHEMBL20070539 0.69 RET (0.47) KDM1AMAOAMAOBRET

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210186959-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA, INC. 2021-06-24 — — US disclosed
US-10172851-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors ARRAY BIOPHARMA INC. (US) 2019-01-08 — — US disclosed
US-20180133213-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-17 — — US disclosed
US-20180133200-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180133200-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, ROR1, BRAF KDM1A 998/4885MAOA 3390/4885MAOB 2737/4885
US-20210186959-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, ROR1, BRAF KDM1A 998/4885MAOA 3390/4885MAOB 2737/4885
US-10172851-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors RET, ROR1, BRAF KDM1A 998/4885MAOA 3390/4885MAOB 2737/4885
US-20180133213-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, ROR1, BRAF KDM1A 998/4885MAOA 3390/4885MAOB 2737/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.