Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 6/20 | 0.60 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.60 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.43 |
| ▸ | MERTK | Q12866 | 1/20 | 0.43 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20070838 | 1.00 | CHRNB2 (0.60) | CHRNB2CHRNA4TLR7LTA4HTRPV6 | |
| SCHEMBL20069989 | 1.00 | CHRNB2 (0.60) | CHRNB2CHRNA4TLR7LTA4HTRPV6 | |
| SCHEMBL22031253 | 1.00 | CHRNB2 (0.60) | CHRNB2CHRNA4TLR7LTA4HTRPV6 | |
| Hydrochloric Acid SCHEMBL31458823 | 0.99 | CHRNB2 (0.59) | CHRNB2CHRNA4TLR7LTA4HTRPV6 | |
| Hydrochloric Acid SCHEMBL20136938 | 0.99 | CHRNB2 (0.59) | CHRNB2CHRNA4TLR7LTA4HTRPV6 | |
| Trifluoroacetic Acid SCHEMBL20136638 | 0.89 | CHRNB2 (0.53) | CHRNB2CHRNA4TLR7LTA4HTRPV6 | |
| SCHEMBL20255464 | 0.83 | CHRNB2 (0.58) | CHRNB2CHRNA4TLR7LTA4HFLT3 | |
| SCHEMBL28921727 | 0.81 | CHRNB2 (0.58) | CHRNB2CHRNA4TLR7LTA4HFLT3 | |
| SCHEMBL20249498 | 0.80 | LTA4H (0.43) | CHRNB2CHRNA4TLR7LTA4HFLT3 | |
| SCHEMBL20160368 | 0.78 | RET (0.47) | CHRNB2CHRNA4TLR7TRPV6KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071447-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |