Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TERT | O14746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20070114 | 0.87 | SMN1; SMN2 (0.49) | SMN1; SMN2LMNAATMHTTPOLB | |
| SCHEMBL20069553 | 0.79 | DPP4 (0.33) | CA1CA2CA9L3MBTL1 | |
| SCHEMBL20069636 | 0.73 | RET (0.54) | KMT2AMEN1LMNACYP2C19TSHR | |
| SCHEMBL316264 | 0.73 | MAPT (0.67) | SMN1; SMN2KMT2AMEN1LMNACYP2C19 | |
| SCHEMBL2921484 | 0.73 | SMN1; SMN2 (0.67) | SMN1; SMN2KMT2AMEN1LMNACYP2C19 | |
| SCHEMBL20070365 | 0.72 | RET (0.43) | SMN1; SMN2KMT2AMEN1LMNACYP2C19 | |
| SCHEMBL20147364 | 0.71 | MEN1 (0.49) | SMN1; SMN2KMT2AMEN1LMNACYP2C19 | |
| SCHEMBL31053543 | 0.71 | SMN1; SMN2 (0.64) | SMN1; SMN2KMT2AMEN1LMNACYP2C19 | |
| SCHEMBL20070112 | 0.71 | BDKRB2 (0.33) | MAPT | |
| SCHEMBL25501931 | 0.71 | SMN1; SMN2 (0.55) | SMN1; SMN2KMT2AMEN1LMNACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |