Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB2 | P30411 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.31 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20069553 | 0.78 | DPP4 (0.33) | BDKRB2DPP4KDM4EOPRM1SLC22A1 | |
| SCHEMBL20069566 | 0.75 | PIK3CD (0.35) | DPP4KDM4EOPRM1SLC22A1SLC6A4 | |
| SCHEMBL20069554 | 0.74 | CYP1A2 (0.37) | BDKRB2OPRM1SLC22A1SLC6A4ADRA1A | |
| SCHEMBL20069607 | 0.73 | ADRB2 (0.46) | BDKRB2DPP4KDM4EOPRM1SLC22A1 | |
| SCHEMBL20070114 | 0.72 | SMN1; SMN2 (0.49) | KDM4E | |
| SCHEMBL20070115 | 0.71 | SMN1; SMN2 (0.52) | MAPT | |
| SCHEMBL20070118 | 0.69 | XIAP (0.35) | DPP4KDM4E | |
| SCHEMBL20069061 | 0.67 | DPP4 (0.36) | DPP4KDM4E | |
| SCHEMBL29290043 | 0.67 | DRD2 (0.38) | — | |
| SCHEMBL20070121 | 0.66 | ALDH1A1 (0.33) | DPP4OPRM1SLC22A1SLC6A4ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |