Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.30 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23555338 | 0.89 | RET (0.35) | EPHX1HSD11B1RETCHRM1JAK3 | |
| SCHEMBL20154522 | 0.82 | NAMPT (0.37) | NAMPTRETJAK3 | |
| SCHEMBL22812265 | 0.78 | NAMPT (0.34) | NAMPTRET | |
| SCHEMBL20149635 | 0.78 | ATM (0.35) | NAMPTRET | |
| SCHEMBL20148736 | 0.78 | NAMPT (0.34) | NAMPTRET | |
| SCHEMBL16456476 | 0.76 | SMN1; SMN2 (0.37) | HSD11B1SMN1; SMN2CHRNB2CHRNA3CHRNA4 | |
| SCHEMBL22030750 | 0.75 | RET (0.33) | RET | |
| SCHEMBL14211238 | 0.73 | SMYD3 (0.36) | NAMPTCHRNB2CHRNA3CHRNA4 | |
| SCHEMBL20153189 | 0.72 | RET (0.36) | RETJAK3 | |
| SCHEMBL21159097 | 0.71 | CHRNB2 (0.39) | HSD11B1SMN1; SMN2CHRM1CHRNB2CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071447-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |