Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR4 | P31391 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 4/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30037140 | 0.87 | CHRNB2 (0.52) | SSTR4HTR1ASLC6A2SLC6A4CHRM1 | |
| SCHEMBL23702833 | 0.87 | CHRNB2 (0.52) | SSTR4HTR1ASLC6A2SLC6A4CHRM1 | |
| SCHEMBL23702832 | 0.87 | CHRNB2 (0.52) | SSTR4HTR1ASLC6A2SLC6A4CHRM1 | |
| SCHEMBL4111572 | 0.83 | HTR1A (0.55) | SSTR4HTR1ASLC6A2SLC6A4PDE10A | |
| Hydrochloric Acid SCHEMBL21752568 | 0.82 | HTR1A (0.53) | SSTR4HTR1ASLC6A2SLC6A4PDE10A | |
| SCHEMBL7709245 | 0.79 | SLC6A2 (0.45) | HTR1ASLC6A2SLC6A4CHRM1 | |
| SCHEMBL21652007 | 0.78 | SSTR4 (0.44) | SSTR4HCRTR1HCRTR2 | |
| Hydrochloric Acid SCHEMBL15134957 | 0.78 | SLC6A2 (0.44) | HTR1ASLC6A2SLC6A4CHRM1 | |
| SCHEMBL21752556 | 0.78 | SLC6A4 (0.49) | HTR1ASLC6A2SLC6A4PDE10A | |
| SCHEMBL15468357 | 0.77 | PDE10A (0.57) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |