Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.35 |
| ▸ | CHRNB3 | Q05901 | 3/20 | 0.35 |
| ▸ | CHRNA6 | Q15825 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 3/20 | 0.32 |
| ▸ | JAK1 | P23458 | 3/20 | 0.32 |
| ▸ | TYK2 | P29597 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20160448 | 0.93 | MAPT (0.42) | MAPTRECQLCNR1CHRNB2CHRNA3 | |
| SCHEMBL21695514 | 0.85 | RECQL (0.48) | RECQLCNR1CHRNB2CHRNA3CHRNA4 | |
| SCHEMBL20071307 | 0.85 | RECQL (0.48) | MAPTRECQLCNR1CHRNB2CHRNA3 | |
| SCHEMBL20071305 | 0.84 | RECQL (0.52) | RECQLCNR1CHRNB2CHRNA3CHRNA4 | |
| SCHEMBL13265396 | 0.83 | MAPT (0.43) | MAPTRECQLCNR1CHRNB2CHRNA3 | |
| SCHEMBL20148606 | 0.81 | MAPT (0.38) | MAPTRECQLCNR1CHRNB2CHRNA3 | |
| SCHEMBL22031235 | 0.81 | HSD11B1 (0.38) | MAPTRECQLCNR1CHRNB2CHRNA3 | |
| SCHEMBL20160445 | 0.81 | RET (0.35) | MAPTRECQLCNR1CHRNB2CHRNA3 | |
| SCHEMBL22031247 | 0.81 | PIK3CD (0.44) | MAPTRECQLCNR1TSHRRET | |
| SCHEMBL20153125 | 0.79 | RET (0.35) | MAPTRECQLCNR1CHRNB2CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3753939-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | Array Biopharma Inc. (US) | 2020-12-23 | — | — | EP | disclosed |
| WO-2018071447-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |