Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 5/20 | 0.39 |
| ▸ | JAK1 | P23458 | 5/20 | 0.39 |
| ▸ | TYK2 | P29597 | 5/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 6/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 6/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.36 |
| ▸ | CHRNB3 | Q05901 | 4/20 | 0.36 |
| ▸ | CHRNA6 | Q15825 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25074013 | 0.90 | ALDH1A1 (0.41) | MAPTHTTRECQLJAK2JAK1 | |
| SCHEMBL20160448 | 0.89 | MAPT (0.42) | MAPTHTTRECQLJAK2JAK1 | |
| SCHEMBL19014503 | 0.84 | JAK2 (0.34) | MAPTHTTRECQLJAK2JAK1 | |
| SCHEMBL19013671 | 0.84 | JAK2 (0.36) | MAPTRECQLJAK2JAK1TYK2 | |
| SCHEMBL20071309 | 0.83 | MAPT (0.41) | MAPTHTTRECQLJAK2JAK1 | |
| SCHEMBL21695514 | 0.82 | RECQL (0.48) | HTTRECQLCNR1CHRNB2CHRNA3 | |
| SCHEMBL20071307 | 0.82 | RECQL (0.48) | MAPTHTTRECQLCNR1CHRNB2 | |
| SCHEMBL19014312 | 0.81 | JAK2 (0.45) | RECQLJAK2JAK1TYK2JAK3 | |
| SCHEMBL20071305 | 0.80 | RECQL (0.52) | RECQLCNR1CHRNB2CHRNA3CHRNA4 | |
| SCHEMBL19014178 | 0.80 | JAK2 (0.36) | JAK2JAK1TYK2JAK3CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7763613-B2 | Substituted N-arylsulfonylheterocyclic amines as gamma-secretase inhibitors | SCHERING CORPORATION (US) | 2010-07-27 | — | — | US | disclosed |